Publication Name	World Journal of Hepatology
Manuscript ID	123456
DOI	10.4254/wjh.123456
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Analysis of risk factors and a prediction model for rebleeding in liver cirrhosis patients with esophagogastric variceal bleeding
Manuscript Source	Unsolicited Manuscript
All Author List	Ping-Ping Li, Xiao Zhong, Da-Ya Zhang and Fei-Hu Bai
Funding Agency and Grant Number	Funding Agency Grant Number the 2025 Hainan Flexible Talent Introduction and Innovation Platform Performance Assessment; the Academic Improvement Support Program of Hainan Medical University No. XSTS2025001 and No. XSTS2026051 Funded Project of the 2026 Undergraduate Scientific Research and Innovation Training Program, Hainan Medical University No. RZ2600001129 the National Clinical Key Specialty Capacity Building Project No. 202330 Hainan Provincial Education Reform Project No. hnjg2024-67 the Joint Scientific and Technological Innovation Project of Health Commission of Hainan Province No. SQ2023WSJK0301
Corresponding Author	Fei-Hu Bai, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, No. 368 Yehai Avenue, Longhua District, Haikou 570216, Hainan Province, China. hy214654@muhn.edu.cn
Key Words	Liver cirrhosis; Esophageal and gastric varices; Esophagogastric variceal rebleeding; Prediction model
Core Tip	This single-center retrospective study enrolled 130 cirrhotic patients with esophagogastric variceal bleeding (EGVB) in 2024 and conducted a one-year follow-up, including 62 rebleeding cases and 68 non-rebleeding cases, aiming to address the high mortality of EGVB rebleeding and the lack of simple non-invasive predictive tools for Hainan population. The study identified four independent risk factors for rebleeding -decreased red blood cell, elevated blood urea nitrogen, ascites, and thickening of the gallbladder wall (TGBW); notably, TGBW was originally validated as a novel non-invasive imaging predictor with an odds ratio value of 0.199 (P < 0.001). A reliable nomogram prediction model was further constructed with an original area under the curve (AUC) of 0.853 and a bootstrap internal validation AUC of 0.855, presenting favorable calibration and clinical applicability. Since this model merely requires routine blood tests and ultrasonic indicators, it can realize convenient and non-invasive risk stratification to guide secondary clinical prevention for local patients. Nevertheless, this research is limited by its retrospective nature, single-center setting and relatively small sample size; and further multi-center prospective studies are required to verify the generalizability of the model.
Citation	Li PP, Zhong X, Zhang DY, Bai. FH Analysis of risk factors and a prediction model for rebleeding in liver cirrhosis patients with esophagogastric variceal bleeding. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.123456
PDF	123456-in-press.pdf

Received	2026-05-25 08:38
Peer-Review Started	2026-05-25 08:39
First Decision by Editorial Office Director
Return for Revision	2026-07-15 02:17
Revised	2026-07-21 06:02
Publication Fee Transferred	2026-07-30 00:07
Second Decision by Editor	2026-08-28 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:22
Articles in Press	2026-08-28 09:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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