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Articles in Press
10/23/2026 9:07:20 AM | Browse: 14 | Download: 0
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
In-depth analysis of cagY in worldwide Helicobacter pylori strains unmasks a strong correlation between sequence diversity and gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mario A López-Luis, Roberto C Torres, Jay V Solnick, M Constanza Camargo, Alfonso Méndez-Tenorio and Javier Torres |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Coordinación de Investigación en Salud, Instituto de Seguro Social Mexico |
No. FIS/IMSS/PROT/PRIO/18/083 |
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| Corresponding Author |
Javier Torres, UIMEIP, Instituto Mexicano del Seguro Social, 330 Cuauhtémoc Avenue, Cuauhtémoc Borough, Alcaldía Doctores, Mexico City 06720, Ciudad de México, Mexico. uimeip@gmail.com |
| Key Words |
Bioinformatics; Helicobacter pylori; cagY; Machine learning; Phenotype association |
| Core Tip |
cagY is a Helicobacter pylori gene with a strong population structure, attesting to an ancient co-evolution with humans. We report that with a proper bioinformatic analyses cagY variants may distinguish patients with gastric cancer (GC) from those with non-atrophic gastritis. The GC-associated variants localized in two relevant regions of cagY, one in a cysteine-enriched repetitive region that sustains the complex structure of the multimer-protein, and the other in a region of the protein that interacts with the epithelial cells. Mutations in these regions might be part of the mechanisms by which cagY modulates the inflammatory response and causes tissue damage. |
| Citation |
López-Luis MA, Torres RC, Solnick JV, Camargo MC, Méndez-Tenorio A, Torres J. In-depth analysis of cagY in worldwide Helicobacter pylori strains unmasks a strong correlation between sequence diversity and gastric cancer. World J Gastroenterol 2026; In press
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Received |
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2026-05-19 07:28 |
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Peer-Review Started |
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2026-05-19 07:30 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 07:54 |
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Revised |
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2026-07-16 17:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-23 02:59 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-23 09:07 |
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Articles in Press |
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2026-10-23 09:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
