Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123488
DOI	10.4251/wjgo.123488
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Up-regulation of protein C contributes to the progression of gastric cancer by modulating MDM2/p53 axis
Manuscript Source	Unsolicited Manuscript
All Author List	Liu Wang, Tian-Yi Fang, Jia-Liang Gao, Yu-Fei Wang, Hong-Wei Li and Ying-Wei Xue
Funding Agency and Grant Number	Funding Agency Grant Number Nn10 Program of Harbin Medical University Cancer Hospital, China No. Nn10 PY 2017-03
Corresponding Author	Ying-Wei Xue, Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China. xueyingwei@hrbmu.edu.cn
Key Words	Gastric cancer; Protein C; MDM2/p53 axis; The Cancer Genome Atlas; Transcriptome
Core Tip	Protein C (PROC) is upregulated in gastric cancer (GC) and acts as an oncogenic driver by modulating the MDM2/p53 axis to promote tumor proliferation, metastasis, and poor survival. Targeting PROC restores p53 activity and suppresses tumor growth, offering a novel therapeutic strategy and prognostic biomarker for GC.
Citation	Wang L, Fang TY, Gao JL, Wang YF, Li HW, Xue YW. Up-regulation of protein C contributes to the progression of gastric cancer by modulating MDM2/p53 axis. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123488
PDF	123488-in-press.pdf

Received	2026-05-20 07:15
Peer-Review Started	2026-05-20 07:15
First Decision by Editorial Office Director	2026-06-08 09:59
Return for Revision	2026-06-10 05:32
Revised	2026-08-08 11:36
Publication Fee Transferred	2026-08-31 14:31
Second Decision by Editor	2026-10-13 06:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-13 09:46
Articles in Press	2026-10-13 09:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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