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Articles in Press
7/2/2026 8:48:49 AM | Browse: 4 | Download: 1
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of UPB1 as a tumor suppressor associated with immune infiltration in cholangiocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Hai Sun, Bi-Cheng Zeng, Jia Sun, Bing-Lu Li and Zu-Yi Ma |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Promotion Program for Clinical Medicine |
No. 2025CMFA08 |
| Beijing Bethune Charitable Foundation |
No. GDZL040 |
| Postdoctoral Fellowship Program of China Postdoctoral Science Foundation |
No. GZC20251430 |
| Sun Yat-sen Pilot Scientific Research Fund |
No. YXQH202608 |
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| Corresponding Author |
Zu-Yi Ma, Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, No. 107 Yanjiang West Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. 13076335286@163.com |
| Key Words |
UPB1; Cholangiocarcinoma; Tumor suppressor; Immune infiltration; Cell cycle; Apoptosis |
| Core Tip |
This study identifies UPB1 as a tumor suppressor in cholangiocarcinoma (CCA). The expression of UPB1 is downregulated in CCA and correlates with adverse clinical features and worse survival. UPB1 overexpression enhances cell apoptosis and triggers G1/S phase arrest. UPB1 expression shows a positive correlation with tumor-infiltrating lymphocytes, and UPB1 overexpression promotes T-cell activation and immune factor release. UPB1 represents a novel prognostic biomarker and a candidate for further investigation in CCA. |
| Citation |
Sun ZH, Zeng BC, Sun J, Li BL, Ma ZY. Identification of UPB1 as a tumor suppressor associated with immune infiltration in cholangiocarcinoma. World J Gastroenterol 2026; In press
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| PDF |
123490-in-press.pdf
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Received |
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2026-05-20 07:52 |
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Peer-Review Started |
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2026-05-20 07:52 |
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First Decision by Editorial Office Director |
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2026-06-04 09:04 |
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Return for Revision |
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2026-06-04 09:04 |
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Revised |
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2026-06-15 09:38 |
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Publication Fee Transferred |
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2026-06-20 13:15 |
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Second Decision by Editor |
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2026-07-02 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-02 08:48 |
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Articles in Press |
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2026-07-02 08:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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