Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123494
DOI	10.4251/wjgo.123494
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mechanisms of the gut-lung axis in regulating lung metastasis of colorectal cancer and advances in traditional Chinese medicine intervention
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-Li Wang, Hu Deng, Ge Wang and Ni-Ni Qu
Funding Agency and Grant Number
Corresponding Author	Ni-Ni Qu, Chief Physician, Respiratory and Critical Care Medicine Department 1/Pulmonary Disease Department 1, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine/Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110000, Liaoning Province, China. qvnini@sina.com
Key Words	Gut-lung axis; Colorectal cancer; Lung metastasis; Traditional Chinese medicine; Microbiota
Core Tip	This review has three main objectives: (1) To analyze the molecular and cellular mechanisms by which the gut-lung axis regulates lung metastasis of colorectal cancer; (2) To critically summarize the evidence for traditional Chinese medicine therapies targeting this axis; and (3) To identify knowledge gaps and propose future research directions. Our main focus is on preclinical studies, as human data is still scarce, but we also discuss the challenges in translational research and the potential of microbiome-based biomarkers.
Citation	Wang GL, Deng H, Wang G, Qu NN. Mechanisms of the gut-lung axis in regulating lung metastasis of colorectal cancer and advances in traditional Chinese medicine intervention. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123494
PDF	123494-in-press.pdf

Received	2026-05-19 11:02
Peer-Review Started	2026-05-19 11:03
First Decision by Editorial Office Director	2026-06-09 11:35
Return for Revision	2026-06-10 01:05
Revised	2026-06-23 10:02
Publication Fee Transferred	2026-06-24 13:58
Second Decision by Editor	2026-08-10 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 10:16
Articles in Press	2026-08-10 10:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com