Publication Name	World Journal of Gastroenterology
Manuscript ID	123529
DOI	10.3748/wjg.123529
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Natural orifice transluminal endoscopic surgery: The true frontier of gastrointestinal endoscopy
Manuscript Source	Unsolicited Manuscript
All Author List	Saif Ullah, Faisal S Ali, Yi-Lin Han, Bing-Rong Liu, Nirav Thosani and Zhuan Liao
Funding Agency and Grant Number	Funding Agency Grant Number the China Postdoctoral Science Foundation No. 2025M784485
Corresponding Author	Zhuan Liao, MD, PhD, Department of Gastroenterology, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China. liaozhuan@smmu.edu.cn
Key Words	Natural orifice transluminal endoscopic surgery; Minimally invasive surgery; Third space endoscopy; Robotic endoscopy; Interventional endoscopy; Magnetic surgery
Core Tip	Natural orifice transluminal endoscopic surgery (NOTES) represents a major frontier in gastrointestinal endoscopy by extending minimally invasive therapy toward truly incisionless intervention. Although early clinical translation was limited by concerns regarding access, closure, infection, hemostasis, spatial orientation, and training, many of these barriers have been progressively addressed through advances in third-space endoscopy, endoscopic suturing, closure devices, hemostatic materials, robotic systems, and magnetic platforms. This opinion review highlights the evolution of NOTES, its current clinical and experimental applications, and the collaborative innovation needed to transform NOTES from a pioneering concept into a safe and practical therapeutic platform.
Citation	Ullah S, Ali FS, Han YL, Liu BR, Thosani N, Liao Z. Natural orifice transluminal endoscopic surgery: The true frontier of gastrointestinal endoscopy. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123529
PDF	123529-in-press.pdf

Received	2026-05-21 06:50
Peer-Review Started	2026-05-21 06:50
First Decision by Editorial Office Director
Return for Revision	2026-06-25 04:26
Revised	2026-07-03 23:48
Publication Fee Transferred	2026-07-24 04:27
Second Decision by Editor	2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-31 10:39
Articles in Press	2026-07-31 10:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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