Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123534
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Synchronous intracholecystic papillary-tubular neoplasm and pancreatic intraductal tubulopapillary neoplasm: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Xia He, Yun-Lu Feng, Zhi-Wen Zhang, Tian-Ming Xu and Jing-Nan Li
Funding Agency and Grant Number	Funding Agency Grant Number ]the National Key R&D Program of China 2025YFC3408700，2025YFC3408701
Corresponding Author	Tian-Ming Xu, MD, Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Dongsheng District, Beijing 100730, China. xutianming@pumch.cn
Key Words	Intracholecystic papillary-tubular neoplasm; Intraductal tubulopapillary neoplasm; Pancreatobiliary tract; Field effect; Case report
Core Tip	Intracholecystic papillary-tubular neoplasm and pancreatic intraductal tubulopapillary neoplasm are usually discussed as related but separate intraductal neoplasms. We report a 30-year-old woman with synchronous multifocal cystic-solid lesions involving the gallbladder and the pancreas. Surgical pathology showed gallbladder intracholecystic papillary-tubular neoplasm with high-grade dysplasia and pancreatic intraductal tubulopapillary neoplasm with multifocal invasive carcinoma. Unlike most reported pancreatic-gallbladder double tumors, this case showed no evident pancreaticobiliary maljunction and involved two intraductal neoplasms. These findings suggest a possible field effect or shared epithelial susceptibility rather than simple reflux-related carcinogenesis, although this hypothesis remains unproven without somatic sequencing or clonality studies.
Citation	He XX, Feng YL, Zhang ZW, Xu TM, Li JN. Synchronous intracholecystic papillary-tubular neoplasm and pancreatic intraductal tubulopapillary neoplasm: A case report. World J Gastrointest Oncol 2026; In press

Received	2026-05-21 06:27
Peer-Review Started	2026-05-21 06:28
First Decision by Editorial Office Director	2026-06-05 02:26
Return for Revision	2026-06-05 09:08
Revised	2026-06-17 07:41
Publication Fee Transferred	2026-06-29 03:37
Second Decision by Editor	2026-07-03 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-03 03:40
Articles in Press	2026-07-03 03:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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