Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123542
DOI	10.4251/wjgo.123542
Country	Australia

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Marked elevation of alpha fetoprotein caused by hepatoid adenocarcinoma of stomach: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Yao Sun, Timothy Elliott, Maddison Johnstone, Matthew Facey, Jong-Khen Chin and Sajith K Gangadharan
Funding Agency and Grant Number
Corresponding Author	Shi-Yao Sun, MD, Department of Gastroenterology, Grampian Health, 1 Drummond St N, Ballarat 3350, Victoria, Australia. sharon.shiyao.sun@gmail.com
Key Words	Gastric cancer; Alpha-fetoprotein; Hepatoid adenocarcinoma; Gastroscopy; Chemotherapy; Case report
Core Tip	We report a rare case of hepatoid adenocarcinoma (HAC). Markedly elevated alpha-fetoprotein levels should prompt physicians to evaluate for uncommon causes including HAC of stomach. Histology and immunohistochemistry are integral to establishing the diagnosis. Gastroscopy is also a crucial diagnostic step. There is currently no established treatment protocol for HAC of stomach; however, treatment for metastatic gastric cancer has been used. A low serum alpha-fetoprotein level is generally associated with better survival, but long-term studies are required to confirm this.
Citation	Sun SY, Elliott T, Johnstone M, Facey M, Chin JK, Gangadharan SK. Marked elevation of alpha fetoprotein caused by hepatoid adenocarcinoma of stomach: A case report. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123542
PDF	123542-in-press.pdf

Received	2026-05-25 07:38
Peer-Review Started	2026-05-25 07:38
First Decision by Editorial Office Director	2026-06-11 09:20
Return for Revision	2026-06-12 23:02
Revised	2026-07-03 16:07
Publication Fee Transferred	2026-07-22 12:38
Second Decision by Editor	2026-08-05 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:49
Articles in Press	2026-08-05 10:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com