Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	123604
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Isolated congenital asplenia with cryptogenic liver fibrosis and a novel SON variant: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Yan Zhang, Yu-Chong Zhao, Li-Ping Chen and Hui-Ling Yu
Funding Agency and Grant Number	Funding Agency Grant Number Hubei Association of Pathophysiology Research Fund 2025HBAP026 Inflammatory Bowel Disease Young Physician Research Fund
Corresponding Author	Hui-Ling Yu, PhD, Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Hankou, Wuhan 430030, Hubei, China. y654au@126.com
Key Words	Isolated congenital asplenia; Liver cirrhosis; SON gene variant; Whole-exome sequencing; Immune regulation; Case report
Core Tip	This case report describes a 33-year-old man with isolated congenital asplenia (ICA) who carries a novel heterozygous SON gene variant, providing a hypothesis-generating clue regarding the genetic basis of ICA. This case highlights the critical challenge of interpreting novel genetic findings in rare congenital anomalies and underscores the need for further studies to elucidate the potential biological significance of SON variants in human disease.
Citation	Zhang YY, Zhao YC, Chen LP, Yu HL. Isolated congenital asplenia with cryptogenic liver fibrosis and a novel SON variant: A case report. World J Gastrointest Surg 2026; In press

Received	2026-05-29 07:40
Peer-Review Started	2026-05-29 07:40
First Decision by Editorial Office Director
Return for Revision	2026-06-16 10:04
Revised	2026-06-27 11:53
Publication Fee Transferred	2026-07-03 12:43
Second Decision by Editor	2026-07-16 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-16 03:46
Articles in Press	2026-07-16 03:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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