Publication Name	World Journal of Nephrology
Manuscript ID	123610
DOI	10.5527/wjn.123610
Country	Brazil

Category	Rheumatology
Manuscript Type	Editorial
Article Title	Fibroblast growth factor 23 in lupus nephritis: A promising biomarker linking renal activity and bone fragility
Manuscript Source	Invited Manuscript
All Author List	Lucas Casagrande Passoni Lopes
Funding Agency and Grant Number
Corresponding Author	Lucas Casagrande Passoni Lopes, Faculdade de Medicina de Bauru, Faculdade de Medicina de Bauru, Universidade de São Paulo, 9-75, Doutor Octávio Pinheiro Brisolla, St, Bauru 17012901, Brazil. lucaspassoni@usp.br
Key Words	Systemic lupus erythematosus; Lupus nephritis; Fibroblast growth factor 23; Biomarker; Renal; Bone fragility
Core Tip	Lupus nephritis is associated not only with progressive renal dysfunction but also with significant bone fragility resulting from chronic inflammation, corticosteroid exposure, and disturbances in mineral metabolism. This editorial discusses the emerging role of fibroblast growth factor-23 (FGF-23) as an integrative biomarker linking renal injury and skeletal impairment in lupus nephritis. Beyond its classical role in phosphate homeostasis, FGF-23 may reflect multisystem disease burden involving inflammation, chronic kidney disease related mineral bone disorder, and abnormal bone remodeling. Understanding the kidney-bone axis in lupus nephritis may support more comprehensive risk stratification and personalized monitoring strategies.
Citation	Lopes LCP. Fibroblast growth factor 23 in lupus nephritis: A promising biomarker linking renal activity and bone fragility. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.123610
PDF	123610-in-press.pdf

Received	2026-06-03 08:56
Peer-Review Started	2026-06-05 05:47
First Decision by Editorial Office Director
Return for Revision	2026-07-09 03:49
Revised	2026-07-12 11:51
Publication Fee Transferred
Second Decision by Editor	2026-08-05 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:49
Articles in Press	2026-08-05 10:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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