Publication Name	World Journal of Diabetes
Manuscript ID	123635
DOI	10.4239/wjd.123635
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Observational Study
Article Title	Expression and clinical value of the plasma peroxiredoxin family in early pregnancy for predicting subsequent gestational diabetes mellitus
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Peng Xu, Shun Ding, Yan-Mei Che, Jing Li, Zhou Zhang and Chen Qian
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Program of Wuxi Health Commission Z202515 Youth Innovation Cultivation Program of Xishan People’s Hospital 202104
Corresponding Author	Chen Qian, Professor, Department of Clinical Laboratory, Central Laboratory, Xishan People’s Hospital of Wuxi City, No. 1128 Dacheng Road, Wuxi 214105, Jiangsu Province, China. qianchenwxxs@163.com
Key Words	Peroxiredoxins; Early gestational diabetes mellitus; Expression; Diagnostic value; Independent risk factors
Core Tip	This study provides the first comprehensive assessment of the plasma peroxiredoxin (PRDX) family in early pregnancy as predictive biomarkers for gestational diabetes mellitus. PRDX1, PRDX4, and PRDX5 demonstrated strong individual diagnostic performance (areas under the curve: 0.757, 0.776, and 0.742, respectively), and their combination further improved accuracy to 0.836. Furthermore, PRDX1 and PRDX3 were identified as independent risk factors for early gestational diabetes mellitus, highlighting the potential of the PRDX family for early screening and risk stratification.
Citation	Xu XP, Ding S, Che YM, Li J, Zhang Z, Qian C. Expression and clinical value of the plasma peroxiredoxin family in early pregnancy for predicting subsequent gestational diabetes mellitus. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.123635
PDF	123635-in-press.pdf

Received	2026-05-25 01:09
Peer-Review Started	2026-05-25 23:58
First Decision by Editorial Office Director	2026-06-03 12:40
Return for Revision	2026-06-03 12:40
Revised	2026-06-10 14:57
Publication Fee Transferred	2026-06-12 03:41
Second Decision by Editor	2026-06-25 08:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 03:44
Articles in Press	2026-07-02 03:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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