Publication Name	World Journal of Cardiology
Manuscript ID	123639
DOI	10.4330/wjc.123639
Country	Indonesia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Effects of 5-methoxytryptophan on cardiac structure and functions in a rat model of diabetic cardiomyopathy
Manuscript Source	Unsolicited Manuscript
All Author List	Susetyo Atmojo, Bambang Budi Siswanto, Nurjati Chairani Siregar, Aria Kekalih, Fadlina Chany Saputri, Budi Susetyo Pikir, Deni Noviana, Apridya Nurhafizah, Riska Ferdian, Wilbert Huang and Puspita Eka Wuyung
Funding Agency and Grant Number
Corresponding Author	Susetyo Atmojo, Consultant, Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central, Jakarta 10430, Indonesia. susetyoatmojo30@gmail.com
Key Words	Diabetic cardiomyopathy; 5-Methoxytryptophan; Cardiac remodeling; Echocardiography; N-terminal pro-B-type natriuretic peptide; Experimental model
Core Tip	Diabetic cardiomyopathy (DCM) is characterized by progressive myocardial remodeling and a lack of therapies that specifically target the underlying inflammatory and fibrotic processes. This study evaluated the effects of 5-methoxytryptophan (5-MTP) in a rat model of DCM. Treatment with 5-MTP significantly reduced N-terminal pro-B-type natriuretic peptide levels and attenuated early structural remodeling but did not improve systolic or diastolic cardiac function. These findings suggest that 5-MTP may influence early myocardial remodeling; however, additional studies are needed to determine whether optimized dosing, longer treatment durations, or other treatment strategies can produce sustained structural and functional benefits.
Citation	Atmojo S, Siswanto BB, Siregar NC, Kekalih A, Saputri FC, Pikir BS, Noviana D, Nurhafizah A, Ferdian R, Huang W, Wuyung PE. Effects of 5-methoxytryptophan on cardiac structure and functions in a rat model of diabetic cardiomyopathy. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.123639
PDF	123639-in-press.pdf

Received	2026-05-27 06:15
Peer-Review Started	2026-05-27 06:15
First Decision by Editorial Office Director	2026-06-09 02:13
Return for Revision	2026-06-09 02:13
Revised	2026-06-19 08:13
Publication Fee Transferred	2026-07-29 02:01
Second Decision by Editor	2026-08-14 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-14 09:38
Articles in Press	2026-08-14 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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