Publication Name	World Journal of Clinical Oncology
Manuscript ID	123640
DOI	10.5306/wjco.123640
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Predictive value of peripheral blood systemic immune-inflammation index and blood cell ratio for gastrointestinal polyp burden in patients with Peutz-Jeghers syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Zu-Xin Xu, Jing Liu, Peng-Fei Yu, Zhi-Wei Dong, Dan Jiang and Guo-Li Gu
Funding Agency and Grant Number
Corresponding Author	Guo-Li Gu, Chief, Director, MD, Department of General Surgery, Air Force Medical Center, Chinese PLA, No. 30 Fucheng Road, Haidian District, Beijing 100142, China. kzggl@163.com
Key Words	Peutz-Jeghers syndrome; Polyps; Blood cell ratios; Systemic immune-inflammation index
Core Tip	This study aimed to analyze the correlations of the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) with clinicopathological features in patients with Peutz-Jeghers syndrome (PJS). Based on correlation analysis and multivariable logistic regression analysis, we constructed and validated a predictive model incorporating SII, NLR, PLR, and MLR to estimate the size and number of small intestinal polyps in PJS patients. This model holds promise as a non-invasive and cost-effective risk stratification marker, thereby facilitating individualized monitoring and early risk intervention.
Citation	Xu ZX, Liu J, Yu PF, Dong ZW, Jiang D, Gu GL. Predictive value of peripheral blood systemic immune-inflammation index and blood cell ratio for gastrointestinal polyp burden in patients with Peutz-Jeghers syndrome. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.123640
PDF	123640-in-press.pdf

Received	2026-06-02 10:25
Peer-Review Started	2026-06-02 10:25
First Decision by Editorial Office Director
Return for Revision	2026-06-22 01:31
Revised	2026-06-28 02:19
Publication Fee Transferred	2026-07-12 12:03
Second Decision by Editor	2026-07-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-14 07:43
Articles in Press	2026-07-14 07:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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