Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	123652
DOI	10.5409/wjcp.123652
Country	Thailand

Category	Pediatrics
Manuscript Type	Clinical Trials Study
Article Title	Shortened eutectic mixture of lidocaine and prilocaine plus skin cooling for pediatric vaccination pain: A randomized non-inferiority trial
Manuscript Source	Unsolicited Manuscript
All Author List	Paveewan Jiravisitkul, Manunya Tandhansakul, Chanikarn Thongkam and Saraiorn Thonginnetra
Funding Agency and Grant Number	Funding Agency Grant Number Chulabhorn Royal Academy through the Research Excellence Group Funding Programmed of Chulabhorn Hospital, Chulabhorn Royal Academy 544/2568
Corresponding Author	Paveewan Jiravisitkul, Principal Investigator, Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, 906 Kamphaeng Phet 6 Road, Talat Bang Khen Subdistrict, Lak Si, Bangkok 10210, Thailand. paveewan.jir@cra.ac.th
Key Words	Pediatric vaccination; Procedural pain; Lidocaine-prilocaine; Skin cooling; Wong-Baker FACES Pain Rating Scale; Non-inferiority trial
Core Tip	In this single-center, open-label, randomized non-inferiority trial conducted with 150 children aged 4-15 years who received a quadrivalent influenza vaccine, a 20-minute topical application of a eutectic mixture of lidocaine and prilocaine combined with 30 seconds of ice-pack skin cooling met the prespecified non-inferiority criterion for post-injection pain when compared with the standard 40-minute eutectic mixture of lidocaine and prilocaine regimen. The intervention reduced the preparation time by a median of 20 minutes. Exploratory analyses suggested fewer mild adverse events at 15 minutes, and caregiver satisfaction was high in both groups. This pragmatic, low-cost protocol is suitable for high-volume primary-care vaccination services.
Citation	Jiravisitkul P, Tandhansakul M, Thongkam C, Thonginnetra S. Shortened eutectic mixture of lidocaine and prilocaine plus skin cooling for pediatric vaccination pain: A randomized non-inferiority trial. World J Clin Pediatr 2026; In press DOI: https://doi.org/10.5409/wjcp.123652
PDF	123652-in-press.pdf

Received	2026-05-25 07:38
Peer-Review Started	2026-05-25 07:38
First Decision by Editorial Office Director
Return for Revision	2026-07-02 06:44
Revised	2026-07-10 15:55
Publication Fee Transferred	2026-07-20 15:34
Second Decision by Editor	2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 12:21
Articles in Press	2026-07-28 12:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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