Publication Name	World Journal of Gastroenterology
Manuscript ID	123662
DOI	10.3748/wjg.123662
Country	Austria

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Steatohepatitic features span molecular subclasses of hepatocellular carcinoma, while intracytoplasmic hyaline bodies associate with mutational status
Manuscript Source	Unsolicited Manuscript
All Author List	Kristijan Skok, Igor Vlašićek, Emina Talakić, Francesca Sarocchi, Marcell Tóth, Konstantin Bräutigam, Karl Kashofer, Mohamed El-Mahrouk, Daniela Kniepeiss, Helmut Schöllnast and Ariane Aigelsreiter
Funding Agency and Grant Number	Funding Agency Grant Number the Swiss National Science Foundation No. P500PM_217647/1
Corresponding Author	Kristijan Skok, Assistant Professor, MD, PhD, Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, Graz 8010, Steiermark, Austria. kristijan.skok@medunigraz.at
Key Words	Hepatocellular carcinoma; Steatohepatitis; Steatosis; Genetics; Carcinogenesis
Core Tip	Hepatocellular carcinoma is a biologically diverse liver cancer. Using histopathological assessment and molecular profiling of 39 hepatocellular carcinomas, we found that steatohepatitic (STH) features occurred across multiple molecular subtypes and were not restricted to the G4 subgroup as previously suggested. Intracytoplasmic hyaline bodies were numerically more frequent in tumors harboring pathogenic genetic alterations. Neither molecular subtype nor STH morphology was associated with patient survival in this cohort. These findings suggest that STH morphology may represent a heterogeneous phenotypic pattern rather than a distinct molecular entity.
Citation	Skok K, Vlašićek I, Talakić E, Sarocchi F, Tóth M, Bräutigam K, Kashofer K, El-Mahrouk M, Kniepeiss D, Schöllnast H, Aigelsreiter A. Steatohepatitic features span molecular subclasses of hepatocellular carcinoma, while intracytoplasmic hyaline bodies associate with mutational status. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123662
PDF	123662-in-press.pdf

Received	2026-06-09 03:21
Peer-Review Started	2026-06-09 03:21
First Decision by Editorial Office Director
Return for Revision	2026-06-18 02:24
Revised	2026-06-29 18:59
Publication Fee Transferred	2026-07-27 06:31
Second Decision by Editor	2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-31 10:44
Articles in Press	2026-07-31 10:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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