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Articles in Press
10/8/2026 9:05:43 AM | Browse: 4 | Download: 0
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
METTL1-mediated N7-methylguanosine modification promotes glycolysis and H4K5 lactylation-dependent Snail-1 activation in pancreatic adenocarcinoma peritoneal metastasis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen Yang, Chen-Zhiang Qiu, Zhi-Gang Yin, Yong Mao, Xiao-Song Ge and Fang Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Fang Wang, PhD, Department of Cancer Diagnosis and Treatment Center, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binghu District, Wuxi 214122, Jiangsu Province, China. wangfang_lukas@jiangnan.edu.cn |
| Key Words |
Pancreatic adenocarcinoma; METTL1; N7-methylguanosine modification; Histone lactylation; Peritoneal metastasis |
| Core Tip |
High METTL1 expression is associated with poor prognosis and peritoneal metastasis in pancreatic adenocarcinoma (PAAD). METTL1 promotes malignant phenotypes and intraperitoneal colonization by directly increasing N7-methylguanosine (m7G) modification of PKM mRNA, leading to PKM2 upregulation, enhanced glycolysis, and lactate accumulation. Elevated lactate specifically drives histone H4K5 lactylation, which activates Snail-1 transcription and subsequent epithelial-mesenchymal transition. This study establishes an RNA m7G modification-glycolysis-histone lactylation regulatory axis, offering novel insights for targeted intervention in PAAD peritoneal metastasis. |
| Citation |
Yang C, Qiu CZA, Yin ZG, Mao Y, Ge XS, Wang F. METTL1-mediated N7-methylguanosine modification promotes glycolysis and H4K5 lactylation-dependent Snail-1 activation in pancreatic adenocarcinoma peritoneal metastasis. World J Gastroenterol 2026; In press
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Received |
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2026-06-01 08:00 |
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Peer-Review Started |
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2026-06-01 08:00 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-26 02:21 |
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Revised |
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2026-07-06 09:39 |
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Publication Fee Transferred |
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2026-07-28 15:34 |
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Second Decision by Editor |
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2026-10-08 07:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:05 |
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Articles in Press |
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2026-10-08 09:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
