Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123676
DOI	10.4251/wjgo.123676
Country	China

Category	Pathology
Manuscript Type	Case Report
Article Title	Primary colonic malignant peripheral nerve sheath tumor with biphasic morphology: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Yue Hu, Jin-Xu He, Xin-Jian Guo and Xiao-Ying Zheng
Funding Agency and Grant Number	Funding Agency Grant Number Qinghai Provincial Science and Technology Department's Innovation Platform Development Support Initiative 2024-SF-L01
Corresponding Author	Xiao-Ying Zheng, MD, PhD, Department of Pathology, The Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. zxy114289181@qq.com
Key Words	Malignant peripheral nerve sheath tumor; Colon; H3K27me3; Biphasic morphology; Case report
Core Tip	Primary malignant peripheral nerve sheath tumor of the colon is exceptionally rare. We report a sporadic colonic case with unusual biphasic spindle and small round cell morphology, complete loss of H3K27me3, and an extremely aggressive postoperative course despite R0 resection. This case highlights the diagnostic difficulty of high-grade mesenchymal malignancies of the colon and underscores the importance of integrating morphology, immunohistochemistry, and H3K27me3 status for accurate diagnosis, as well as the need for close postoperative surveillance.
Citation	Hu JY, He JX, Guo XJ, Zheng XY. Primary colonic malignant peripheral nerve sheath tumor with biphasic morphology: A case report. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123676
PDF	123676-in-press.pdf

Received	2026-05-26 06:05
Peer-Review Started	2026-05-26 06:05
First Decision by Editorial Office Director	2026-06-05 03:39
Return for Revision	2026-06-05 03:39
Revised	2026-06-15 12:36
Publication Fee Transferred	2026-06-26 03:51
Second Decision by Editor	2026-06-30 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-30 05:18
Articles in Press	2026-06-30 05:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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