Publication Name	World Journal of Diabetes
Manuscript ID	123687
DOI	10.4239/wjd.123687
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Association of triglyceride-glucose-derived insulin resistance indices with first metatarsophalangeal joint cartilage thickness in type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Shan Li, Xiao-Hui Xiao, Yang Li, Yu-Ying Cai, Ping-Xiang Hu and Hong Li
Funding Agency and Grant Number
Corresponding Author	Hong Li, MD, Department of Ultrasound, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chinese Medicine Hospital), No. 1 Fuhua Road, Futian District, Shenzhen 518000, Guangdong Province, China. lihong_echo@163.com
Key Words	Insulin resistance surrogates; Cartilage thickness; First metatarsophalangeal joint; Type 2 diabetes mellitus; High-frequency ultrasound
Core Tip	This cross-sectional study of 98 patients with type 2 diabetes (196 first metatarsophalangeal joints) is, to our knowledge, the first to investigate the association between four triglyceride-glucose (TyG)-derived insulin resistance surrogates (i.e., TyG index, TyG-body mass index, TyG-waist circumference, TyG-waist-to-height ratio) and ultrasound measured cartilage thickness. Using generalized estimating equations to account for within-subject correlations from bilateral joint measurements, we found that all four indices were independently associated with lower cartilage thickness. Prospective studies are required to confirm these findings and establish causality.
Citation	Li QS, Xiao XH, Li Y, Cai YY, Hu PX, Li H. Association of triglyceride-glucose-derived insulin resistance indices with first metatarsophalangeal joint cartilage thickness in type 2 diabetes. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.123687
PDF	123687-in-press.pdf

Received	2026-05-27 00:59
Peer-Review Started	2026-05-28 00:01
First Decision by Editorial Office Director
Return for Revision	2026-06-26 01:32
Revised	2026-07-23 12:27
Publication Fee Transferred	2026-08-11 04:03
Second Decision by Editor	2026-10-19 03:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 05:38
Articles in Press	2026-11-05 05:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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