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Articles in Press
9/4/2026 10:21:34 AM | Browse: 23 | Download: 7
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Gut microbiota derived butyrate suppresses colorectal cancer via phosphoinositide three kinase and protein kinase B signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Ge, Long Qian, Wen Jiang, Lei Zheng, Jin Wang, Mao-Kun Feng, Yi-Mei Zhu, Meng-Jun Wang, Sha-Sha Sun, Jing Rui and Mao-Qi Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Research Project of Higher Education Institutions of Anhui Province, China |
No. 2023AH053197 |
| Key Project of the Wuhu Municipal Health Commission, China |
No. WHWJ2023y044 |
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| Corresponding Author |
Mao-Qi Xu, Chief Physician, Professor, Department of General Surgery, Anhui Wannan Rehabilitation Hospital, Fifth People’s Hospital of Wuhu, No. 3 Zheshan East Road, Jinghu District, Wuhu 241000, Anhui Province, China. xumaoqi2020@163.com |
| Key Words |
Colorectal cancer; Faecalibacterium prausnitzii; Sodium butyrate; Apoptosis; Histone deacetylase activity; Phosphoinositide 3-kinase/protein kinase B signaling |
| Core Tip |
Faecalibacterium prausnitzii extract and sodium butyrate selectively inhibited proliferation and promoted apoptosis in six colorectal cancer cell lines without significantly affecting normal colorectal cells. Faecalibacterium prausnitzii also reduced tumor growth in mice. Inhibitor of trichostatin A-1 partially reversed these effects, linking the observed responses to histone deacetylase activity and phosphoinositide 3-kinase/protein kinase B-related signaling changes. However, the findings remain associative and do not establish a direct causal pathway. |
| Citation |
Ge Y, Qian L, Jiang W, Zheng L, Wang J, Feng MK, Zhu YM, Wang MJ, Sun SS, Rui J, Xu MQ. Gut microbiota derived butyrate suppresses colorectal cancer via phosphoinositide three kinase and protein kinase B signaling. World J Gastrointest Oncol 2026; In press
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| PDF |
123706-in-press.pdf
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Received |
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2026-06-23 10:27 |
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Peer-Review Started |
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2026-06-23 10:27 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-07 05:47 |
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Revised |
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2026-07-20 01:27 |
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Publication Fee Transferred |
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2026-07-28 01:10 |
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Second Decision by Editor |
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2026-09-02 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-04 10:21 |
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Articles in Press |
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2026-09-04 10:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
