Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123710
DOI	10.4251/wjgo.123710
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-Li Chen and Jian-Hua Liu
Funding Agency and Grant Number
Corresponding Author	Jian-Hua Liu, Chief Physician, Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, No. 215 West Heping Road, Shijiazhuang 050000, Hebei Province, China. 26300372@hebmu.edu.cn
Key Words	Tensin4; C-terminal tensin-like; Slug; Hepatocellular carcinoma; HepG2 cells; PLC cells; Transforming growth factor-β1; Epithelial-mesenchymal transformation
Core Tip	This study showed that tensin (TNS) 4 was highly expressed in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis. TNS4 may regulate Slug expression to mediate epithelial-mesenchymal transition via the transforming growth factor-β1/Smad signaling pathway, promoting proliferation, migration and invasion of HCC cells. TNS4 is expected to be a novel therapeutic target for HCC and merits further in-depth research.
Citation	Chen GL, Liu JH. Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123710
PDF	123710-in-press.pdf

Received	2026-05-27 06:48
Peer-Review Started	2026-05-27 06:48
First Decision by Editorial Office Director
Return for Revision	2026-06-22 12:56
Revised	2026-07-04 06:30
Publication Fee Transferred	2026-07-24 14:36
Second Decision by Editor	2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-31 09:38
Articles in Press	2026-07-31 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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