Publication Name	World Journal of Psychiatry
Manuscript ID	123719
DOI	10.5498/wjp.123719
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Coordinated dysregulation of the hippocampus-amygdala-prefrontal cortex circuit in anxiety and depressive disorders: A narrative review
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Zhao, Wei Zhang, Dan Xu and Xing-An Liu
Funding Agency and Grant Number
Corresponding Author	Xing-An Liu, Department of Neurological Rehabilitation III, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Shenyang 110032, Liaoning Province, China. liuxing_an@126.com
Key Words	Anxiety disorders; Depressive disorders; Hippocampus; Amygdala; Prefrontal cortex; Functional connectivity; Emotional regulation; Neural circuit
Core Tip	This review highlights that anxiety and depressive disorders involve dysregulation of the hippocampus-amygdala-prefrontal cortex circuit, rather than isolated regional dysfunction. In anxiety, disruption of this circuit promotes hypervigilance to threats and the generalization of fear; in depression, it underlies negative memory bias and cognitive inflexibility. Comorbidity involves the reciprocal reinforcement of threat anticipation and negative memory. This circuit-based perspective links clinical phenomenology to neurobiology, guiding the development of biomarkers and interventions.
Citation	Zhao X, Zhang W, Xu D, Liu XA. Coordinated dysregulation of the hippocampus-amygdala-prefrontal cortex circuit in anxiety and depressive disorders: A narrative review. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.123719
PDF	123719-in-press.pdf

Received	2026-06-02 10:40
Peer-Review Started	2026-06-02 10:40
First Decision by Editorial Office Director
Return for Revision	2026-06-17 01:58
Revised	2026-06-27 03:15
Publication Fee Transferred	2026-06-30 02:22
Second Decision by Editor	2026-07-10 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-10 06:08
Articles in Press	2026-07-10 06:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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