Publication Name	World Journal of Radiology
Manuscript ID	123720
DOI	10.4329/wjr.123720
Country	Netherlands

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Comparing the reliability of three software programmes for manual and (semi-)automatic volumetry in healthy livers
Manuscript Source	Unsolicited Manuscript
All Author List	Ariadne Lisa van der Velden, Robrecht R M M Knapen, Sinéad James, Hossein Rahmani, Ralph Brecheisen, Sander M J van Kuijk, Joachim E Wildberger, Ronald R M M van Dam and Christiaan van der Leij
Funding Agency and Grant Number
Corresponding Author	Christiaan van der Leij, Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, Maastricht 6229 HX, Limburg, Netherlands. christiaan.vander.leij@mumc.nl
Key Words	Liver malignancy; Liver volumetry software; (Semi)automated segmentation; Manual segmentation; Imaging-based volumetry
Core Tip	This study compared three software programs (semi-automatic and manual) for computed tomography-based liver volumetry in 200 patients. Total liver volume and segment II/III volume – used as a surrogate for the future liver remnant – showed excellent interobserver agreement and strong agreement between all three software programs. Although Synapse 3D, Syngo.via, and OsiriX® produced small systematic differences in absolute volume estimates, the standardized future liver remnant remained comparable. These findings indicate that all three programs can provide reliable liver volumetry, while highlighting that absolute measurements should be interpreted in relation to the software used.
Citation	van der Velden AL, Knapen RRMM, James S, Rahmani H, Brecheisen R, van Kuijk SMJ, Wildberger JE, van Dam RRMM, van der Leij C. Comparing the reliability of three software programmes for manual and (semi-)automatic volumetry in healthy livers. World J Radiol 2026; In press DOI: https://doi.org/10.4329/wjr.123720
PDF	123720-in-press.pdf

Received	2026-05-27 06:27
Peer-Review Started	2026-05-27 06:31
First Decision by Editorial Office Director
Return for Revision	2026-07-14 08:36
Revised	2026-07-24 15:19
Publication Fee Transferred
Second Decision by Editor	2026-08-25 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-25 09:30
Articles in Press	2026-08-25 09:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8470 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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