Publication Name	World Journal of Gastroenterology
Manuscript ID	123728
DOI	10.3748/wjg.123728
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Optimizing Helicobacter pylori eradication and cardiovascular risk assessment in long-term aspirin users: Methodological perspective
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Yu, Xing-Yong Huang, Xiao-Yue Zhang, Yi-Jia Sun, Peng Lu, Shou-Liang Cai and Kai Zhang
Funding Agency and Grant Number
Corresponding Author	Kai Zhang, MD, PhD, Department of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. zhangkaidoctor@163.com
Key Words	Helicobacter pylori; Aspirin; Peptic ulcer bleeding; Cardiovascular disease; Real-world evidence
Core Tip	Semeya et al provided exceptional real-world evidence of the benefits of Helicobacter pylori eradication for chronic aspirin users. To further upgrade this multidisciplinary clinical model, we discuss the safety boundaries of intensified alternative therapies in elderly patients and the specific pathophysiological cascades driving vascular stability. Rather than universal screening, we propose a highly targeted, risk-stratified surveillance approach utilizing advanced imaging to safely balance clinical justification with cost-effectiveness thresholds.
Citation	Yu X, Huang XY, Zhang XY, Sun YJ, Lu P, Cai SL, Zhang K. Letter to the Editor: Optimizing Helicobacter pylori eradication and cardiovascular risk assessment in long-term aspirin users: Methodological perspective. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123728
PDF	123728-in-press.pdf

Received	2026-05-28 07:04
Peer-Review Started	2026-05-28 07:04
First Decision by Editorial Office Director
Return for Revision	2026-07-01 03:29
Revised	2026-07-13 02:00
Publication Fee Transferred
Second Decision by Editor	2026-07-27 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 12:05
Articles in Press	2026-07-28 12:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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