Publication Name	World Journal of Diabetes
Manuscript ID	123730
DOI	10.4239/wjd.123730
Country	China

Category	Anesthesiology
Manuscript Type	Basic Study
Article Title	Preventive carnosine supplementation attenuates painful diabetic neuropathy via restoring mitochondrial function and suppressing inflammasome activation
Manuscript Source	Unsolicited Manuscript
All Author List	Zhuo-Ying Yu, Jing Yang, Ye Jiang, Yong-Zheng Han, Min Wei, Jia-Yin Shou, Shi-Xiong Shen, Yan-Han Lyu, Xin-Sheng Li, Qian Chen, Xin-Ru Zhao, Guo-Gang Xing, Da-Qing Ma and Min Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82001329 and 82071411 Beijing Municipal Natural Science Foundation No. 7204325 Key Research Foundation of Peking University Third Hospital No. BYSYZD2019036 Special Fund of the National Clinical Key Specialty Construction Program, China (2025)
Corresponding Author	Min Li, Chief Physician, Deputy Director, MD, Professor, Department of Anesthesiology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. liminanesth@bjmu.edu.cn
Key Words	Painful diabetic neuropathy; Mitochondrial fission; Dynamin-related protein 1; NOD-like receptor pyrin domain-containing protein 3 inflammasome; Carnosine
Core Tip	Painful diabetic neuropathy (PDN) is characterized by impaired mitochondrial function and reduced carnosine levels in the dorsal root ganglia. Untargeted metabolomic analysis identified carnosine deficiency as a metabolic alteration associated with PDN. Preventive carnosine supplementation alleviated behavioral, electrophysiological, and mitochondrial abnormalities in diabetic rats and was associated with reduced dynamin-related protein 1-related mitochondrial fission and NOD-like receptor pyrin domain-containing protein 3 inflammasome activation in dorsal root ganglia. These findings were further supported by complementary in vitro experiments, collectively supporting further preclinical and translational evaluation of carnosine as a potential early-intervention strategy for PDN.
Citation	Yu ZY, Yang J, Jiang Y, Han YZ, Wei M, Shou JY, Shen SX, Lyu YH, Li XS, Chen Q, Zhao XR, Xing GG, Ma DQ, Li M. Preventive carnosine supplementation attenuates painful diabetic neuropathy via restoring mitochondrial function and suppressing inflammasome activation. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.123730
PDF	123730-in-press.pdf

Received	2026-06-02 07:34
Peer-Review Started	2026-06-05 05:49
First Decision by Editorial Office Director
Return for Revision	2026-06-25 07:09
Revised	2026-07-08 06:46
Publication Fee Transferred	2026-07-20 11:52
Second Decision by Editor	2026-08-18 09:56
Second Decision by Editor-in-Chief	2026-08-20 10:45
Final Decision by Editorial Office Director	2026-09-04 09:43
Articles in Press	2026-09-04 09:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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