Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123758
DOI	10.4251/wjgo.123758
Country	China

Category	Oncology
Manuscript Type	Observational Study
Article Title	Application of fecal DNA multi-gene methylation testing in colorectal cancer screening in Haikou City
Manuscript Source	Unsolicited Manuscript
All Author List	Run-Yu Chen, Da-Ya Zhang, Yu-Liang Huang, Jun-Min Yao, Xiao Zhong, Ping-Ping Li and Fei-Hu Bai
Funding Agency and Grant Number	Funding Agency Grant Number Flexible Talent Introduction Collaborative Innovation Center, Hainan Medical University Academic Enhancement Support Program XSTS2025001 Flexible Talent Introduction Collaborative Innovation Center, Hainan Medical University Academic Enhancement Support Program XSTS2026051 Joint Project on Health Science and Technology Innovation in Hainan Province WSJK2024MS150 Hainan Medical University Undergraduate Research Innovation Program RZ2600001129 Hainan Province Education Reform Project hnjg2024-67 National Clinical Key Specialty Capacity Building Project 202330
Corresponding Author	Fei-Hu Bai, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, No. 368 Yehai Avenue, Longhua District, Haikou 570216, Hainan Province, China. hy214654@muhn.edu.cn
Key Words	Colorectal cancer; Fecal DNA methylation; Syndecan 2; Alcohol dehydrogenase, iron containing 1; Protein phosphatase 2 regulatory subunit B’ gamma; Positive predictive value; Early screening
Core Tip	This cross-sectional study evaluated fecal DNA multi-gene methylation testing (syndecan 2/alcohol dehydrogenase, iron containing 1/protein phosphatase 2 regulatory subunit B’ gamma) in 4050 participants in Haikou City, Hainan Province, China. The test demonstrated a high positive predictive value (85.2%) for detecting colorectal lesions and identified independent risk factors associated with positive screening results, such as older age, Helicobacter pylori infection, high-salt diet, and pickled food consumption. These findings support its potential as a non-invasive colorectal cancer screening tool in Hainan Province.
Citation	Chen RY, Zhang D, Huang YL, Yao JM, Zhong X, Li PP, Bai FH. Application of fecal DNA multi-gene methylation testing in colorectal cancer screening in Haikou City. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123758

Received	2026-05-28 06:09
Peer-Review Started	2026-05-28 06:09
First Decision by Editorial Office Director	2026-06-11 00:54
Return for Revision	2026-06-11 00:54
Revised	2026-06-22 14:59
Publication Fee Transferred	2026-06-30 15:52
Second Decision by Editor	2026-07-06 08:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-06 08:22
Articles in Press	2026-07-06 08:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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