Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	123771
DOI	10.4291/wjgp.123771
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mapping the new frontier: Current perspectives on evolving gastrointestinal pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Gautam Ray
Funding Agency and Grant Number
Corresponding Author	Gautam Ray, Chief, Director, MD, Postdoc, Gastroenterology Unit, Department of Medicine, B.R. Singh Railway Hospital, Sealdah, Kolkata 700014, West Bengal, India. gautam1910@yahoo.com
Key Words	Gastrointestinal pathophysiology; Intestinal mucosa; Brain-gut axis; Artificial intelligence; Gastrointestinal microbiome; Systems biology; Enteric nervous system; Biomedical engineering
Core Tip	Rapid advancement in cutting edge basic research in genetics, multi-omics, bioengineering and artificial intelligence has transitioned the field of gastrointestinal pathophysiology from organ-centric models to a systems-biology approach which highlight the complex crosstalk between the gut microbiome, the enteric nervous system, the mucosal immune system, and the enteroendocrine system, producing systemic effects. This narrative review will highlight three primary pathophysiological mechanisms, namely the role of the epithelial barrier integrity, the metabolic influence of the microbiome, and the gut microbiota-distant organ axis in disease pathogenesis. The utility of artificial intelligence and bioengineering models in shaping future therapy will be discussed.
Citation	Ray G. Mapping the new frontier: Current perspectives on evolving gastrointestinal pathophysiology. World J Gastrointest Pathophysiol 2026; In press DOI: https://doi.org/10.4291/wjgp.123771
PDF	123771-in-press.pdf

Received	2026-05-29 07:23
Peer-Review Started	2026-05-29 07:24
First Decision by Editorial Office Director
Return for Revision	2026-07-03 08:56
Revised	2026-08-08 08:43
Publication Fee Transferred
Second Decision by Editor	2026-10-09 03:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:44
Articles in Press	2026-10-09 09:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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