Publication Name	World Journal of Hepatology
Manuscript ID	123791
DOI	10.4254/wjh.123791
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Molecular characteristics and carcinogenic mechanisms of aflatoxin B1-associated hepatocellular carcinoma: Recent advances
Manuscript Source	Unsolicited Manuscript
All Author List	Fei Li, Qin-Qin Long, Feng-Qin Tian, Mei-Jin Huang and Xi‐Dai Long
Funding Agency and Grant Number	Funding Agency Grant Number Baise Talent Highland 2020-3-2 Building Projects of Guangxi Bagui Scholars Guirencaiban-2024-39 Building Projects of Key Laboratory of Tumor Molecular Pathology (Youjiang Medical University for Nationalities), Education Department of Guangxi Zhuang Autonomous Region Guijiaokeyan-2022-10 Building Projects of the Key Laboratory of Molecular Pathology in Tumor of Baise 2022 Clinical Key Specialty Building Project (For Pathology) of Guangxi Guiweiyifa-2022-21 Building Projects from the Key Laboratory of Molecular Pathology (Hepatobiliary Diseases) of Guangxi Guiweikejiaofa-2020-17
Corresponding Author	Xi‐Dai Long, MD, PhD, Professor, Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Youjiang, Zhongshan 2nd Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. sjtulongxd@263.net
Key Words	Aflatoxin B1-related hepatocellular carcinoma; Molecular characteristics; Carcinogenic mechanism; DNA adduct; TP53 mutation; Epigenetics; Biomarker; Precision medicine
Core Tip	Aflatoxin B1 (AFB1) is a potent carcinogen characterized by hepatotropism, genotoxicity and carcinogenicity. AFB1-associated hepatocellular carcinoma (AAHCC) possesses distinct molecular profiles (including TP53 R249S mutation, C > A transversion, GCN motif preference, strand bias and abnormal epigenetic modifications) and pathogenic mechanisms (including the formation of AFB1-exo-8,9-epoxide and AFB1-DNA adducts, abnormal DNA damage repair, and the accumulation of somatic mutation), exhibiting substantial heterogeneity from non-AFB1-associated hepatocellular carcinoma.
Citation	Li F, Long QQ, Tian FQ, Huang MJ, Long XD. Molecular characteristics and carcinogenic mechanisms of aflatoxin B1-associated hepatocellular carcinoma: Recent advances. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.123791
PDF	123791-in-press.pdf

Received	2026-05-29 07:43
Peer-Review Started	2026-05-29 07:43
First Decision by Editorial Office Director
Return for Revision	2026-07-07 06:50
Revised	2026-07-16 06:52
Publication Fee Transferred	2026-07-23 08:38
Second Decision by Editor	2026-07-30 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-30 10:41
Articles in Press	2026-07-30 10:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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