Publication Name	World Journal of Gastroenterology
Manuscript ID	123806
DOI	10.3748/wjg.123806
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Quercetin overcomes gemcitabine resistance in pancreatic cancer by targeting TOP2A and WNT-β-catenin signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Kang Deng, Li Zhang, Tao-Fang Meng, Sheng Wang, Chen Chen, Ou Qiao and Yun Jin
Funding Agency and Grant Number	Funding Agency Grant Number Yunnan Provincial Clinical Medical Center for Digestive System Diseases Project No. 2024YNLCYXZX0140 Yunnan Province Science and Technology Talents and Platform Plan-Workstation No. 202305AF150148
Corresponding Author	Yun Jin, Department of Hepatobiliary and Pancreatic Surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650034, Yunnan Province, China. 20150041@kust.edu.cn
Key Words	Quercetin; TOP2A; Gemcitabine-resistance; WNT-β-catenin; Pancreatic-cancer; Radix-Bupleuri
Core Tip	Quercetin from Radix Bupleuri overcomes gemcitabine resistance in pancreatic cancer by targeting TOP2A and promoting its ubiquitin-mediated degradation, thereby inhibiting WNT-β-catenin signaling, suppressing malignant behaviors, and enhancing gemcitabine efficacy both in vitro and in vivo.
Citation	Deng SK, Zhang L, Meng TF, Wang S, Chen C, Qiao O, Jin Y. Quercetin overcomes gemcitabine resistance in pancreatic cancer by targeting TOP2A and WNT-β-catenin signaling. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123806
PDF	123806-in-press.pdf

Received	2026-06-01 08:38
Peer-Review Started	2026-06-01 08:38
First Decision by Editorial Office Director
Return for Revision	2026-06-22 03:08
Revised	2026-07-04 04:56
Publication Fee Transferred
Second Decision by Editor	2026-11-12 06:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-12 09:56
Articles in Press	2026-11-12 09:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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