Publication Name	World Journal of Cardiology
Manuscript ID	123807
DOI	10.4330/wjc.123807
Country	Italy

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Methodology vs reality - deciphering cardiovascular safety of proton pump inhibitors in dual antiplatelet therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Elia De Maria
Funding Agency and Grant Number
Corresponding Author	Elia De Maria, MD, Arrhythmology Lab, Cardiology Unit, Ramazzini Hospital, Via Molinari 1, Carpi 41012, Modena, Italy. e.demaria@inwind.it
Key Words	Proton pump inhibitors; Clopidogrel; Drug-drug interaction; Dual antiplatelet therapy; Percutaneous coronary intervention
Core Tip	The combination of proton pump inhibitor and dual antiplatelet therapy, in patients undergoing percutaneous coronary intervention, has raised concerns because of the risk of drug-drug interaction potentially reducing clopidogrel efficacy and increasing ischemic risk. A recent meta-analysis, by methodically isolating randomized data from observational biases, proved that the increased cardiovascular risk seen in prior literature was a product of patient-level confounding rather than true biological harm and provided reassurance regarding the safety of combining proton pump inhibitors with clopidogrel.
Citation	De Maria E. Letter to the Editor: Methodology vs reality - deciphering cardiovascular safety of proton pump inhibitors in dual antiplatelet therapy. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.123807
PDF	123807-in-press.pdf

Received	2026-06-03 08:54
Peer-Review Started	2026-06-03 08:54
First Decision by Editorial Office Director
Return for Revision	2026-06-23 08:18
Revised	2026-06-24 08:29
Publication Fee Transferred
Second Decision by Editor	2026-07-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-09 03:22
Articles in Press	2026-07-09 03:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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