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Articles in Press
10/8/2026 9:06:41 AM | Browse: 3 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Phenotypic age acceleration predicts gallstone disease and acute biliary complications: A United Kingdom Biobank cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi Wang, Hai-Feng Wang, Hou-Ru Li, Li-Fang Chen, Zhen-Zhen Zhang, He-Zhao Li, Jia-Hao Li, Henry Tong and Ke-Feng Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Macao Science and Technology Development Fund (FDCT) |
0033/2023/RIB2 |
| Joint Fund between FDCT and the Department of Science and Technology of Guangdong Province |
0009/2024/AGJ |
| Joint Fund between FDCT and the Ministry of Science and Technology of China |
0106/2025/AMJ |
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| Corresponding Author |
Ke-Feng Li, Associate Professor, PhD, Faculty of Applied Sciences, Macao Polytechnic University, R. de Luís Gonzaga Gomes, Macau 999078, Macao SR, China. kefengl@mpu.edu.mo |
| Key Words |
Phenotypic age acceleration; Gallstone disease; Cholangitis; Plasma protein mediation; Risk stratification |
| Core Tip |
This study tested whether phenotypic age acceleration could indicate the risk of gallstone disease across the full biliary spectrum in 414756 United Kingdom Biobank participants. The aging signal was able to predict gallstone disease and three acute biliary complications. These four outcomes were jointly scored by Biliary Time-aware Multi-outcome model from routine blood biomarkers. The model was also able to link the risk to plasma proteins through mediation analysis in 53014 proteomic participants. In particular, the top proteins CSF1, PLAUR, and GDF15 converged on the cytokine receptor pathway hubbed by interleukin 6 and tumor necrosis factor. This shared pathway explains why one aging measure could flag four biliary outcomes at once, whereas these outcomes are usually managed as separate diseases. |
| Citation |
Wang Z, Wang HF, Li HR, Chen LF, Zhang ZZ, Li HZ, Li JH, Tong H, Li KF. Phenotypic age acceleration predicts gallstone disease and acute biliary complications: A United Kingdom Biobank cohort study. World J Gastroenterol 2026; In press
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Received |
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2026-06-01 09:23 |
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Peer-Review Started |
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2026-06-01 09:24 |
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First Decision by Editorial Office Director |
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2026-06-11 10:00 |
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Return for Revision |
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2026-06-11 10:00 |
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Revised |
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2026-07-17 07:17 |
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Publication Fee Transferred |
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2026-08-05 08:48 |
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Second Decision by Editor |
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2026-10-08 07:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:06 |
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Articles in Press |
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2026-10-08 09:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
