Publication Name	World Journal of Stem Cells
Manuscript ID	123837
DOI	10.4252/wjsc.123837
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Exosomal miR-148a-3p from adipose derived stem cells promotes microglial M2 polarization and alleviates traumatic brain injury via the TMEM9B/NF-κB axis
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Bo Hui, Xi Wang, Teng-Da Qian, Xiao-Kui Gan and Li-Xin Li
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Province Capability Improvement Project through Science, Technology and Education ZDXK202225
Corresponding Author	Li-Xin Li, Department of Neurosurgery, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. lilixin2@hotmail.com
Key Words	Traumatic brain injury; Exosome; Adipose-derived stem cells; MiR-148a-3p; Microglial polarization; Transmembrane protein 9B; Cytokines; Neurogenesis; Rat model; Inflammation
Core Tip	This study reveals that exosomes derived from adipose-derived stem cells deliver miR-148a-3p to microglia, where it directly targets transmembrane protein 9B and suppresses the nuclear factor-kappa B signaling pathway. This mechanism drives microglial polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype, thereby reducing neuroinflammation and improving neurological recovery in a rat model of traumatic brain injury. The specificity of the miR-148a-3p/transmembrane protein 9B/nuclear factor-kappa B axis was confirmed by a rescue experiment, identifying a novel therapeutic target for neuroinflammatory disorders.
Citation	Hui XB, Wang X, Qian TD, Gan XK, Li LX. Exosomal miR-148a-3p from adipose derived stem cells promotes microglial M2 polarization and alleviates traumatic brain injury via the TMEM9B/NF-κB axis. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.123837
PDF	123837-in-press.pdf

Received	2026-06-10 11:04
Peer-Review Started	2026-06-10 11:04
First Decision by Editorial Office Director
Return for Revision	2026-06-30 02:40
Revised	2026-08-03 08:24
Publication Fee Transferred	2026-09-02 03:04
Second Decision by Editor	2026-10-13 03:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:09
Articles in Press	2026-11-02 03:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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