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Articles in Press
8/25/2026 9:53:50 AM | Browse: 16 | Download: 7
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Ginsenoside Rd promote the contact between mitochondria and lipid droplets through Plin1/Mfn2 to treat diabetic kidney disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Bin Wu, Yi Tao, Nai-Jia Xu, Qing-Qing Shao, Fen Yuan, Hui Dong, Fu-Er Lu, Cheng-Hong Zheng and Fan Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82405337 |
| Natural Science Foundation of Hubei Province of China |
No. 2024AFB489 |
| Wuhan Natural Science Foundation Exploration Program (Chenguang Program) |
No. 2025020701020243 |
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| Corresponding Author |
Fan Wu, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Hua Zhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. 18202729109@163.com |
| Key Words |
Ginsenoside Rd; Diabetic kidney disease; Perilipin 1; Lipid droplet; Mitochondria |
| Core Tip |
This study identifies the protein kinase A/perilipin (Plin) 1/mitofusin 2 axis as a novel therapeutic target for diabetic kidney disease. Ginsenoside Rd activates protein kinase A, promotes Plin1-mitofusin 2 interaction, enhances lipid droplet-mitochondria contact, and stimulates fatty acid oxidation, thereby attenuating renal lipid accumulation and fibrosis. Using in vivo and in vitro loss of function models, we demonstrate that Plin1 is essential for ginsenoside Rd induced organelle tethering and metabolic benefit, providing a mechanistic framework for diabetic kidney disease intervention. |
| Citation |
Wu WB, Tao Y, Xu NJ, Shao QQ, Yuan F, Dong H, Lu FE, Zheng CH, Wu F. Ginsenoside Rd promote the contact between mitochondria and lipid droplets through Plin1/Mfn2 to treat diabetic kidney disease. World J Diabetes 2026; In press
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| PDF |
123886-in-press.pdf
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Received |
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2026-06-30 03:20 |
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Peer-Review Started |
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2026-07-02 00:01 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-09 08:04 |
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Revised |
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2026-07-17 03:37 |
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Publication Fee Transferred |
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2026-07-28 11:16 |
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Second Decision by Editor |
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2026-08-10 09:33 |
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Second Decision by Editor-in-Chief |
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2026-08-14 04:26 |
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Final Decision by Editorial Office Director |
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2026-08-25 09:53 |
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Articles in Press |
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2026-08-25 09:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
