BPG is committed to discovery and dissemination of knowledge
Articles in Press
9/22/2026 9:48:14 AM | Browse: 19 | Download: 1
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Metabolic dysfunction-associated fatty liver and antiviral response in chronic hepatitis B: A systematic review and meta-analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia Liu, Peng Zhang, Ke-Zhen Hu, Zhi-Hui Zhao, Yong-Ning Xin and Yan-Zhen Bi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82202416 |
| the China Hepatitis Prevention and Control Foundation Mu Xin Chronic Hepatitis B Research Fund |
No. MX202409 |
| the Beijing iGandan Foundation Clinical Research Project |
No. iGandanF-1082024-LG002 |
|
| Corresponding Author |
Yan-Zhen Bi, PhD, Department of Infectious Disease, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No. 1 Jiaozhou Road, Shibei District, Qingdao 266011, Shandong Province, China. byzh199009@163.com |
| Key Words |
Metabolic dysfunction-associated fatty liver disease; Chronic hepatitis B; Antiviral therapy; Meta-analysis; Systematic review; Clinical outcomes |
| Core Tip |
Metabolic dysfunction-associated fatty liver disease (MAFLD) frequently coexists with chronic hepatitis B, but its clinical implications remain unclear. This meta-analysis showed that MAFLD was associated with lower rates of hepatitis B virus DNA clearance and alanine aminotransferase normalization, with no significant difference in hepatitis B e antigen seroclearance, and treatment duration-specific and regimen-specific differences in hepatitis B surface antigen seroclearance. MAFLD was also associated with higher odds of hepatocellular carcinoma, although this finding was influenced by diagnostic approach and showed limited robustness. These results support incorporating metabolic risk assessment into the long-term management of chronic hepatitis B. |
| Citation |
Liu J, Zhang P, Hu KZ, Zhao ZH, Xin YN, Bi YZ. Metabolic dysfunction-associated fatty liver and antiviral response in chronic hepatitis B: A systematic review and meta-analysis. World J Gastroenterol 2026; In press
|
| PDF |
123905-in-press.pdf
|
 |
Received |
|
2026-06-02 08:25 |
|
Peer-Review Started |
|
2026-06-02 08:25 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-07-23 06:26 |
|
Revised |
|
2026-08-04 14:03 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-09-22 03:46 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-09-22 09:48 |
|
Articles in Press |
|
2026-09-22 09:48 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
|
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
