Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	123931
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: From association to mechanism - advancing the understanding of small intestinal bacterial overgrowth in acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Shree V Dhotre, Pradnya S Dhotre and Basavraj S Nagoba
Funding Agency and Grant Number
Corresponding Author	Basavraj S Nagoba, PhD, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagba@yahoo.com
Key Words	Small intestinal bacterial overgrowth; Acute pancreatitis; Glucose hydrogen breath test; Gut-pancreas axis; Dysbiosis; Methane; Intestinal motility; Gut barrier dysfunction
Core Tip	The prospective study by Kumbar et al represents an important step toward understanding the relationship between small intestinal bacterial overgrowth and acute pancreatitis. Beyond confirming a high prevalence of small intestinal bacterial overgrowth, the findings raise broader questions regarding host-microbiome interactions, intestinal methanogen overgrowth, microbial biomarkers of disease severity, and precision therapeutic strategies. Future studies integrating breath testing with microbiome sequencing, metabolomic profiling, and longitudinal clinical assessment may determine whether microbial alterations are merely markers of disease severity or active contributors to pancreatic inflammation and systemic complications.
Citation	Dhotre SV, Dhotre PS, Nagoba BS. Letter to the Editor: From association to mechanism - advancing the understanding of small intestinal bacterial overgrowth in acute pancreatitis. World J Gastrointest Pharmacol Ther 2026; In press

Received	2026-06-02 10:25
Peer-Review Started	2026-06-02 10:32
First Decision by Editorial Office Director
Return for Revision	2026-07-14 07:23
Revised	2026-07-20 06:34
Publication Fee Transferred
Second Decision by Editor	2026-07-27 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 10:02
Articles in Press	2026-07-27 10:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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