Publication Name	World Journal of Gastroenterology
Manuscript ID	123934
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Organoids as preclinical platforms for metabolic dysfunction-associated steatotic liver disease: Model construction, mechanistic dissection, and therapeutic translation
Manuscript Source	Unsolicited Manuscript
All Author List	Hao-Yu Xue, Tian-Yi Ren, Qin Pan and Jian-Gao Fan
Funding Agency and Grant Number	Funding Agency Grant Number the Noncommunicable Chronic Diseases-National Science and Technology Major Project 023ZD0508700 the National Natural Science Foundation of China 82470600 the Construction Project of the “Discipline Peak-Climbing Plan” of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine XKPF2024B401 and the Postdoctoral Research Startup Fund of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 2025BS02
Corresponding Author	Jian-Gao Fan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Organoid; Disease modeling; Mechanism
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, yet targeted therapeutic options are limited. This review systematically summarizes liver organoids derived from human pluripotent stem cells, primary tissues, and immortalized cell lines in MASLD research, highlighting their distinct advantages in modeling MASLD pathogenesis, elucidating mechanisms, screening biomarkers, and validating therapeutics. It further discusses multi-tissue organoid systems, alongside current challenges and future directions to accelerate clinical translation and advance personalized medicine for MASLD.
Citation	Xue HY, Ren TY, Pan Q, Fan JG. Organoids as preclinical platforms for metabolic dysfunction-associated steatotic liver disease: Model construction, mechanistic dissection, and therapeutic translation. World J Gastroenterol 2026; In press

Received	2026-06-03 07:34
Peer-Review Started	2026-06-03 07:34
First Decision by Editorial Office Director
Return for Revision	2026-07-20 06:07
Revised	2026-07-30 04:34
Publication Fee Transferred	2026-08-11 03:06
Second Decision by Editor	2026-09-07 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-08 09:38
Articles in Press	2026-09-08 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com