Publication Name	World Journal of Orthopedics
Manuscript ID	123952
DOI	10.5312/wjo.123952
Country	Finland

Category	Orthopedics
Manuscript Type	Retrospective Study
Article Title	Long-term functional and quality-of-life outcomes after knee replacement in patients with inherited bleeding disorders: A 15-year follow-up study
Manuscript Source	Unsolicited Manuscript
All Author List	Heidi Danielson, Pekka Ylinen, Riitta Lassila, Leena Ristolainen, Jouni Lohikoski, Hannu Kautiainen and Timo Yrjönen
Funding Agency and Grant Number	Funding Agency Grant Number Orton Research Grants, Ministry of Social Affairs and Health, Finland A2500/422
Corresponding Author	Heidi Danielson, MD, Research Institute Orton, Joint Replacement Orton Hospital, Tenholantie 10, Helsinki 00280, Uusimaa, Finland. heidi.danielson@icloud.com
Key Words	Hemophilia; von Willebrand disease; Bleeding disorder; Knee replacement; Total knee arthroplasty; Hungerford knee score
Core Tip	Long-term outcome data after total knee replacement (TKR) in patients with inherited bleeding disorders (BDs) are scarce. This study provides very long-term follow-up data, with a mean follow-up duration of 15 years. Patients achieved sustained improvements in functional capacity and favorable quality-of-life outcomes, with results comparable to those of patients undergoing knee replacement for primary osteoarthritis. These findings support TKR as an effective treatment for advanced arthropathy associated with inherited BDs.
Citation	Danielson H, Ylinen P, Lassila R, Ristolainen L, Lohikoski J, Kautiainen H, Yrjönen T. Long-term functional and quality-of-life outcomes after knee replacement in patients with inherited bleeding disorders: A 15-year follow-up study. World J Orthop 2026; In press DOI: https://doi.org/10.5312/wjo.123952
PDF	123952-in-press.pdf

Received	2026-06-02 07:36
Peer-Review Started	2026-06-02 07:37
First Decision by Editorial Office Director	2026-06-09 04:11
Return for Revision	2026-06-09 04:11
Revised	2026-06-30 12:29
Publication Fee Transferred	2026-07-13 07:42
Second Decision by Editor	2026-08-07 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 10:23
Articles in Press	2026-08-10 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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