Publication Name	World Journal of Hepatology
Manuscript ID	123969
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Therapeutic efficacy and multitarget mechanisms of traditional Chinese medicine in hereditary liver diseases: Insights into bioactive components
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Juan Tang, Ke-Yi Feng, Zhen-Jie Zhuang, Hong-Yi Wang, Mei-Yin Wu, Peng-Hua Li, Jun-Ping Shi and Xiao-Xiao Mi
Funding Agency and Grant Number	Funding Agency Grant Number Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China LHDMZ24H030001 National Natural Science Foundation of China 82470599 Hangzhou Municipal Health and Wellness Project 2023WJC149
Corresponding Author	Xiao-Xiao Mi, Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhoulu, Hangzhou 310015, Zhejiang Province, China. mixiaoxiao1987@163.com
Key Words	Hereditary liver diseases; Traditional Chinese medicine; Bioactive components; Multitarget mechanisms; Translational medicine
Core Tip	This review highlights the therapeutic potential of traditional Chinese medicine in hereditary liver diseases, emphasizing its proposed multitarget mechanisms, regulating ion homeostasis, oxidative stress, cell death, and gut-liver axis. It explores bioactive components (alkaloids and flavonoids) and compound formulas (e.g., Gandouling Decoction) guided by Jun-Chen-Zuo-Shi principles, addressing challenges (bioavailability and quality control) and future directions (multiomics and nanotechnology) to complement western medicine via holistic, mechanism-based therapy.
Citation	Tang MJ, Feng KY, Zhuang ZJ, Wang HY, Wu MY, Li PH, Shi JP, Mi XX. Therapeutic efficacy and multitarget mechanisms of traditional Chinese medicine in hereditary liver diseases: Insights into bioactive components. World J Hepatol 2026; In press

Received	2026-06-02 10:09
Peer-Review Started	2026-06-02 10:09
First Decision by Editorial Office Director
Return for Revision	2026-06-29 02:42
Revised	2026-07-02 09:08
Publication Fee Transferred	2026-07-13 00:22
Second Decision by Editor	2026-07-27 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 09:59
Articles in Press	2026-07-27 09:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com