Publication Name	World Journal of Cardiology
Manuscript ID	123995
DOI	10.4330/wjc.123995
Country	Croatia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Correspondence
Article Title	Reply: Culprit coronary occlusion as a stronger short-term prognostic marker over electrocardiographic pattern in acute myocardial infarction
Manuscript Source	Unsolicited Manuscript
All Author List	Nikola Kos, Ivan Zeljković, Karlo Golubic, Vjekoslav Radeljic, Marijan Erceg, Maja Cigrovski Berkovic, Diana Delic-Brkljacic and Nikola Bulj
Funding Agency and Grant Number
Corresponding Author	Nikola Kos, Department of Cardiology, University Hospital Centre Sestre Milosrdnice, Vinogradska 29, Zagreb 10000, Croatia. nikolakos89@gmail.com
Key Words	Infarct-related artery occlusion; Electrocardiographic presentation; Acute myocardial infarction; Troponin; Statin therapy; Microvascular obstruction; OMI/NOMI
Core Tip	This response emphasizes that angiographic occlusion status is a strong independent prognostic marker in acute myocardial infarction (AMI), providing information beyond electrocardiographic classification and peak troponin levels. The persistent independent association with mortality suggests mechanisms beyond infarct size alone—including microvascular dysfunction and no-reflow—warranting investigation as hypotheses in future prospective studies. The association between chronic statin therapy and lower likelihood of total occlusion may reflect plaque-stabilizing effects, though requiring prospective validation. These findings support the emerging OMI/NOMI paradigm as superior to traditional electrocardiography-based AMI classification for risk stratification.
Citation	Kos N, Zeljković I, Golubic K, Radeljic V, Erceg M, Cigrovski Berkovic M, Delic-Brkljacic D, Bulj N. Reply: Culprit coronary occlusion as a stronger short-term prognostic marker over electrocardiographic pattern in acute myocardial infarction. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.123995
PDF	123995-in-press.pdf

Received	2026-06-04 02:00
Peer-Review Started	2026-06-05 05:43
First Decision by Editorial Office Director
Return for Revision	2026-06-17 02:37
Revised	2026-06-23 09:17
Publication Fee Transferred
Second Decision by Editor	2026-07-06 03:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-06 06:51
Articles in Press	2026-07-06 06:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com