Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124022
DOI	10.4251/wjgo.124022
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Propensity score-based real-world study of immune checkpoint inhibitor combination therapy in microsatellite stable/proficient mismatch repair metastatic colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Chang Zhang, Shi-Hao Wu, Lei Jin, Liang Lu, Ji Li and Shui Jin
Funding Agency and Grant Number
Corresponding Author	Shui Jin, Department of Gastroenterology, The Fourth Affiliated Hospital of Anhui Medical University, No. 64 Chaohu North Road, Juchao District, Chaohu, Hefei 238000, Anhui Province, China. e-ch2009640010@fy.ahmu.edu.cn
Key Words	Metastatic colorectal cancer; Microsatellite stable; Immune checkpoint inhibitors; Anti-angiogenic therapy; Inflammatory biomarkers
Core Tip	Immune checkpoint inhibitors have limited efficacy in microsatellite stable/proficient mismatch repair metastatic colorectal cancer. This real-world study showed that immune checkpoint inhibitor-based combination therapy with chemotherapy and anti-angiogenic agents was associated with improved progression-free survival after propensity score adjustment. Liver metastasis and tumor sidedness showed exploratory prognostic and treatment-related signals, although subgroup findings require further validation. Post-treatment neutrophil‑to‑lymphocyte ratio and systemic immune‑inflammation index may provide additional risk stratification value. These findings offer clinically relevant evidence supporting further prospective evaluation of immune checkpoint inhibitor-based combination strategies in microsatellite stable/proficient mismatch repair metastatic colorectal cancer.
Citation	Zhang C, Wu SH, Jin L, Lu L, Li J, Jin S. Propensity score-based real-world study of immune checkpoint inhibitor combination therapy in microsatellite stable/proficient mismatch repair metastatic colorectal cancer. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124022
PDF	124022-in-press.pdf

Received	2026-06-05 06:41
Peer-Review Started	2026-06-05 06:41
First Decision by Editorial Office Director
Return for Revision	2026-07-13 09:44
Revised	2026-07-27 08:55
Publication Fee Transferred	2026-08-14 12:20
Second Decision by Editor	2026-09-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-10 09:21
Articles in Press	2026-09-10 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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