Publication Name	World Journal of Psychiatry
Manuscript ID	124037
DOI	10.5498/wjp.124037
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Association between systemic immune-inflammation index and symptoms of depression and anxiety in type 2 diabetes mellitus patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Yu Pan, Yi-Kun Wang, Ya-Qin Ding, Nuo-Jin Wang, Tian-Rong Pan and Xing Zhong
Funding Agency and Grant Number	Funding Agency Grant Number Health Research Program of Anhui AHWJ2023BAc10010 Clinical and Translational Research Project of Anhui Province 202427b10020055 National Natural Science Foundation of China 32571507
Corresponding Author	Xing Zhong, Professor, Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Economic and Technological Development Zone, Hefei 230601, Anhui Province, China. zhongxing@ahmu.edu.cn
Key Words	Anxiety; Depression; Systemic immune-inflammatory index; Type 2 diabetes mellitus; 9-item Patient Health Questionnaire; 7-item Generalized Anxiety Disorder
Core Tip	Chronic inflammation is implicated in the psychological comorbidities of type 2 diabetes mellitus (T2DM). This cross-sectional study enrolling 402 hospitalized T2DM patients reveals that elevated systemic immune-inflammation index is independently associated with higher prevalence of elevated depressive symptoms, anxiety symptoms and their comorbidity, presenting a significant non-linear dose-response pattern. Systemic immune-inflammatory index may act as an auxiliary inflammatory biomarker for psychological symptom stratification in hospitalized T2DM patients.
Citation	Pan XY, Wang YK, Ding YQ, Wang NJ, Pan TR, Zhong X. Association between systemic immune-inflammation index and symptoms of depression and anxiety in type 2 diabetes mellitus patients. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.124037
PDF	124037-in-press.pdf

Received	2026-06-04 03:07
Peer-Review Started	2026-06-04 03:07
First Decision by Editorial Office Director
Return for Revision	2026-07-06 08:06
Revised	2026-07-13 12:30
Publication Fee Transferred	2026-08-03 13:23
Second Decision by Editor	2026-08-28 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:27
Articles in Press	2026-08-28 09:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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