Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124040
DOI	10.4251/wjgo.124040
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Elevated pretreatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predict poor survival in cholangiocarcinoma: A large-scale meta-analysis of 48 cohorts
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Miao Cai, Wei Jiang, Bao-Feng He, Jun-Jie Yu, Xian-Hua Zeng, Lei Peng and Sun Liu
Funding Agency and Grant Number
Corresponding Author	Lei Peng, Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Zhongshan Avenue, Guangzhou 510000, Guangdong Province, China. 1015425249@qq.com
Key Words	Cholangiocarcinoma; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Prognosis; Meta-analysis
Core Tip	Pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio serve as significant prognostic biomarkers for cholangiocarcinoma. This meta-analysis of 48 cohorts confirms that elevated NLR and platelet-to-lymphocyte ratio correlate with poorer overall and disease-free survival. Notably, NLR demonstrates superior predictive value in patients receiving palliative therapy compared to those undergoing curative surgery. These findings suggest NLR is a valuable tool for risk stratification in unresectable cases. However, the lack of standardized cut-off values necessitates cautious clinical application and further prospective validation before routine implementation.
Citation	Cai WM, Jiang W, He BF, Yu JJ, Zeng XH, Peng L, Liu S. Elevated pretreatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predict poor survival in cholangiocarcinoma: A large-scale meta-analysis of 48 cohorts. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124040
PDF	124040-in-press.pdf

Received	2026-06-04 03:07
Peer-Review Started	2026-06-04 03:07
First Decision by Editorial Office Director
Return for Revision	2026-07-15 02:30
Revised	2026-07-16 10:41
Publication Fee Transferred	2026-07-24 06:34
Second Decision by Editor	2026-07-30 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-30 10:45
Articles in Press	2026-07-30 10:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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