Publication Name	World Journal of Stem Cells
Manuscript ID	124057
DOI	10.4252/wjsc.124057
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Restoration of inflammatory responsiveness by metformin in endothelial cells derived from Marfan syndrome patient-specific induced pluripotent stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Hao Chen, Min-Jie Hu, Jin-Biao Lai, Lu Ding, Mi-Qi Zhou, Run-Ze Dong, Xiao-Li Ren, Cong-Kuo Du, Xue-Jiao Chen, Xiu-Fang Chen, Xiao-Fang Fan, Yong-Sheng Gong, Yong-Yu Wang and Pei-Feng Jin
Funding Agency and Grant Number	Funding Agency Grant Number Wenzhou Municipal Science and Technology Bureau of China ZY2022009
Corresponding Author	Pei-Feng Jin, Department of Cardiac Surgery, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou 325000, Zhejiang Province, China. ericifeng@163.com
Key Words	Marfan syndrome; Endothelial dysfunction; Patient-specific induced pluripotent stem cells; Inflammatory responses; Thoracic aortic aneurysm and dissection; Metformin; Resveratrol
Core Tip	This study establishes a patient-specific endothelial cell model of Marfan syndrome (MFS) and identifies an inflammatory phenotype characterized by heightened basal inflammation but impaired responsiveness to inflammatory stimuli. These findings provide new insights into endothelial dysfunction in MFS. Importantly, metformin and resveratrol exert distinct anti-inflammatory effects, with metformin partially restoring inflammatory responsiveness and resveratrol suppressing basal inflammation, highlighting their potential as complementary therapeutic strategies for reducing vascular risk in MFS.
Citation	Chen YH, Hu MJ, Lai JB, Ding L, Zhou MQ, Dong RZ, Ren XL, Du CK, Chen XJ, Chen XF, Fan XF, Gong YS, Wang YY, Jin PF. Restoration of inflammatory responsiveness by metformin in endothelial cells derived from Marfan syndrome patient-specific induced pluripotent stem cells. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.124057
PDF	124057-in-press.pdf

Received	2026-07-14 10:59
Peer-Review Started	2026-07-14 10:59
First Decision by Editorial Office Director
Return for Revision	2026-08-05 03:30
Revised	2026-09-04 10:07
Publication Fee Transferred	2026-10-09 02:35
Second Decision by Editor	2026-11-13 03:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-13 10:24
Articles in Press	2026-11-13 10:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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