Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124061
DOI	10.4251/wjgo.124061
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Ferroptosis-mitochondria-related molecular subtypes and prognostic signature reveal immune and pathway heterogeneity in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Shan Han, Zhi-Wei Feng, Yun Ran, Gui-Ping Ma, Yi-Chi Zhou, Jin-Zhen Lv, Xiao-Bin Li, Cong-Hui Wang, Long-Zhu Wang and Shi-Ping Hu
Funding Agency and Grant Number	Funding Agency Grant Number General Program of the Guangdong Basic and Applied Basic Research Foundation 2025A1515011796 Guangdong Provincial Enterprise Joint Fund 2023A1515220096 General Program of the Shenzhen Natural Science Foundation JCYJ20240813165129038 Open Project of the National Key Laboratory for Integration and Innovation of Classical Formulas and Modern Chinese Medicine LSLSKL20240117 Sanming Project of Medicine in Shenzhen SZZYSM202311018
Corresponding Author	Shi-Ping Hu, Chief Physician, Full Professor, PhD, Department of Hepatology, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), No. 1 Dayun Road, Longgang District, Shenzhen 518172, Guangdong Province, China. 13153441966@163.com
Key Words	Hepatocellular carcinoma; Ferroptosis; Mitochondria; Prognostic signature; Immune cell scores; Bioinformatics
Core Tip	This study integrated ferroptosis- and mitochondria-related genes to characterize hepatocellular carcinoma heterogeneity and develop a six-gene prognostic score. Four molecular subtypes showed distinct survival and immune-score patterns. Internal validation supported short- and intermediate-term discrimination, whereas performance weakened at 5 years, and Kaplan-Meier separation after risk-group dichotomization was not statistically significant in the external cohorts. The principal contribution is a compact, biologically interpretable framework linking ferroptosis, mitochondrial dysfunction, immune remodeling, and metabolic pathway alterations in hepatocellular carcinoma.
Citation	Han S, Feng ZW, Ran Y, Ma GP, Zhou YC, Lv JZ, Li XB, Wang CH, Wang LZ, Hu SP. Ferroptosis-mitochondria-related molecular subtypes and prognostic signature reveal immune and pathway heterogeneity in hepatocellular carcinoma. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124061
PDF	124061-in-press.pdf

Received	2026-06-08 07:35
Peer-Review Started	2026-06-08 07:35
First Decision by Editorial Office Director	2026-06-15 08:20
Return for Revision	2026-06-15 08:20
Revised	2026-06-27 13:26
Publication Fee Transferred	2026-07-10 09:57
Second Decision by Editor	2026-08-20 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-20 08:48
Articles in Press	2026-08-20 08:48
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Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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