Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124094
DOI	10.4251/wjgo.124094
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and systemic immune-inflammation index predict survival in HER2-negative advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Zheng, Jing Chen and Meng-Ting Li
Funding Agency and Grant Number
Corresponding Author	Xin Zheng, Chief Physician, Clinical Laboratory, Laboratory Department, Chuzhou Hospital Affiliated to Anhui Medical University (Chuzhou First People's Hospital), Chuzhou 239000, Anhui China, Department of Laboratory Medicine, Chuzhou Hospital Affiliated to Anhui Medical University (Chuzhou First People’s Hospital), 369 Zuiweng West Road, Nanqiao District, Chuzhou City, Anhui Province, Chuzhou 239000, Anhui Province, China. sunnyacmilan@163.com
Key Words	Inflammatory markers; HER2-negative; Advanced gastric cancer; Survival outcomes; Predictive value
Core Tip	This retrospective cohort study of 262 patients with human epidermal growth factor receptor 2-negative advanced gastric cancer demonstrates that pretreatment peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) are independent predictors of overall survival. Elevated NLR, PLR, and SII were risk factors, while elevated LMR was protective. The combined four marker nomogram achieved an area under the curve of 0.764, offering a simple, cost-effective tool for early risk stratification and treatment optimization in this population.
Citation	Zheng X, Chen J, Li MT. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and systemic immune-inflammation index predict survival in HER2-negative advanced gastric cancer. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124094
PDF	124094-in-press.pdf

Received	2026-06-05 11:36
Peer-Review Started	2026-06-05 11:37
First Decision by Editorial Office Director
Return for Revision	2026-06-22 02:14
Revised	2026-06-30 08:58
Publication Fee Transferred	2026-07-08 02:09
Second Decision by Editor	2026-08-28 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:28
Articles in Press	2026-08-28 09:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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