Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124096
DOI	10.4251/wjgo.124096
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Activating transcription factor 4-mediated alanine-serine-cysteine transporter 2 promotes colorectal cancer proliferation
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Xia Wang, Di Zhang, Xin-Long Shi, Xue-Dong Zhang, Hong-Lai Zhang, Xiong-Fei Yang, Xi-Wen Pang, Fa-Xin Li and Tao Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82160522 the General Project of Gansu Provincial Science and Technology Department Joint Research Fund No. 23JRRA1540 the Lanzhou Science and Technology Talent Innovation Project No. 2023-QN-17
Corresponding Author	Tao Wang, Additional Professor, MD, PhD, Department of Anorectal Surgery, Gansu Provincial people’s Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. wt831030@126.com
Key Words	Activating transcription factor 4; Alanine-serine-cysteine transporter 2; Glutamine metabolism; Mechanistic target of rapamycin complex 1 signaling pathway; Colorectal cancer
Core Tip	Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Glutamine (Gln) metabolism and mechanistic target of rapamycin complex 1 (mTORC1) signaling are crucial for tumor growth. This study reveals that activating transcription factor 4 (ATF4) directly upregulates the Gln transporter alanine-serine-cysteine transporter 2, which mediates Gln uptake, activates mTORC1 signaling, and promotes CRC proliferation. Our findings are consistent with a proposed ATF4-alanine-serine-cysteine transporter 2-mTORC1 positive feedback loop in CRC, which requires direct functional validation of the reciprocal mTORC1/URB1→ATF4 arm.
Citation	Wang C, Zhang D, Shi X, Zhang X, Zhang H, Yang X, Pang X, Li F, Wang T. Activating transcription factor 4-mediated alanine-serine-cysteine transporter 2 promotes colorectal cancer proliferation. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124096
PDF	124096-in-press.pdf

Received	2026-06-08 07:35
Peer-Review Started	2026-06-08 07:35
First Decision by Editorial Office Director
Return for Revision	2026-08-04 07:02
Revised	2026-08-30 14:43
Publication Fee Transferred	2026-09-17 14:39
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:22
Articles in Press	2026-11-04 10:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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