Publication Name	World Journal of Virology
Manuscript ID	124097
Country	Türkiye

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Metagenomic next-generation sequencing in the diagnosis of viral encephalitis
Manuscript Source	Invited Manuscript
All Author List	Umut Devrim Binay, Faruk Karakeçili, Orçun Barkay and Betül Sümer
Funding Agency and Grant Number
Corresponding Author	Umut Devrim Binay, Associate Professor, MD, Department of Infectious Diseases and Clinical Microbiology, Erzincan Binali Yildirim University, Faculty of Medicine, Hacı Ali Akın Street, Basbaglar District, Erzincan 24000, Türkiye. umut.binay@erzincan.edu.tr
Key Words	Viral encephalitis; Metagenomic next-generation sequencing; Neuroinfection; Viral diagnostics; Central nervous system infections
Core Tip	Metagenomic next-generation sequencing broadens the diagnostic search in viral encephalitis by detecting pathogen nucleic acids without a predefined target. Its highest value is in severe, unexplained, atypical, or immunocompromised cases after urgent targeted testing and empirical treatment have started. It performs less reliably when pathogen burden is low, infection is tissue-restricted, or diagnosis depends mainly on serology. Results therefore require contamination controls, clinical correlation, and confirmatory testing. Metagenomic next-generation sequencing complements rather than replaces polymerase chain reaction, serology, and conventional microbiology.
Citation	Binay UD, Karakeçili F, Barkay O, Sümer B. Metagenomic next-generation sequencing in the diagnosis of viral encephalitis. World J Virol 2026; In press

Received	2026-06-08 01:03
Peer-Review Started	2026-06-08 01:03
First Decision by Editorial Office Director
Return for Revision	2026-07-23 03:26
Revised	2026-07-27 12:13
Publication Fee Transferred
Second Decision by Editor	2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:41
Articles in Press	2026-08-26 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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