Publication Name	World Journal of Hepatology
Manuscript ID	124108
DOI	10.4254/wjh.124108
Country	Israel

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Acute hepatitis B in the vaccination era: Predictors of functional cure and chronicity
Manuscript Source	Unsolicited Manuscript
All Author List	David Yardeni, Julianna Gershbaum Tobin, Bryan Itkowitz, Inna Lipnizkiy, Ali Abu Juma’a, Naim Abu-Freha, Ayelet Keren-Naus, May Turgeman, Anat Nevo-Shor, Robert Gareth Gish and Ohad Etzion
Funding Agency and Grant Number
Corresponding Author	David Yardeni, MD, Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, 151 Rager Blvd., Beersheba 84101, Southern, Israel. yardeda@post.bgu.ac.il
Key Words	Hepatitis B; Diabetes mellitus; Socioeconomic status; Vaccination; Nucleos(t)ide analogues
Core Tip	The widespread availability of the universal hepatitis B virus (HBV) vaccination reduced acute HBV incidence in developed countries. Acute HBV usually resolves with functional cure in > 95% of adults. In our study we evaluated all acute HBV cases in southern Israel between 2004-2022 and found a striking 34% chronicity rate. Further analysis revealed that a background of diabetes and low socioeconomic status were found to strongly predict chronic infection. These findings highlight the need for risk stratification in acute HBV patients from vulnerable populations.
Citation	Yardeni D, Gershbaum Tobin J, Itkowitz B, Lipnizkiy I, Abu Juma’a A, Abu-Freha N, Keren-Naus A, Turgeman M, Nevo-Shor A, Gish RG, Etzion O. Acute hepatitis B in the vaccination era: Predictors of functional cure and chronicity. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124108
PDF	124108-in-press.pdf

Received	2026-06-08 02:00
Peer-Review Started	2026-06-08 02:01
First Decision by Editorial Office Director
Return for Revision	2026-06-25 16:45
Revised	2026-06-30 16:51
Publication Fee Transferred	2026-07-28 03:07
Second Decision by Editor	2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-31 10:43
Articles in Press	2026-07-31 10:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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