Publication Name	World Journal of Translational Medicine
Manuscript ID	124147
DOI	10.5528/wjtm.124147
Country	Egypt

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Perspectives on the bioenergetic dysregulation in insulin-resistant patients comorbid with cancer
Manuscript Source	Invited Manuscript
All Author List	Dina Johar, Khaled Mahmoud and Samy Zaky
Funding Agency and Grant Number
Corresponding Author	Dina Johar, PhD, Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Asma Fahme Street, Heliopolis, Cairo 11757, Egypt. dinajohar@gu.edu.eg
Key Words	Insulin resistance; Platelets; Cancer; Dipeptidyl peptidase 4; Mitochondrial bioenergetics
Core Tip	This perspective proposes that insulin-resistant cancer patients exhibit reduced platelet mitochondrial bioenergetics compared to non-insulin-resistant cancer patients or healthy controls, and that platelet mitochondrial profiling may serve as an early marker of mitochondrial dysfunction in this population. It further hypothesizes that dipeptidyl peptidase 4 inhibition may ameliorate insulin resistance in cancer patients and proposes a cell culture model to test this hypothesis. The article’s clinical relevance lies in potentially identifying non-invasive biomarkers for metabolic dysfunction in cancer patients and exploring dipeptidyl peptidase 4 inhibitors as therapeutics. Strengths include the integration of cancer biology, metabolic syndrome pathophysiology, and mitochondrial bioenergetics, and the proposal of testable frameworks.
Citation	Johar D, Mahmoud K, Zaky S. Perspectives on the bioenergetic dysregulation in insulin-resistant patients comorbid with cancer. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.124147
PDF	124147-in-press.pdf

Received	2026-06-09 02:38
Peer-Review Started	2026-06-09 02:38
First Decision by Editorial Office Director
Return for Revision	2026-07-07 06:39
Revised	2026-07-19 16:26
Publication Fee Transferred
Second Decision by Editor	2026-08-10 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 10:44
Articles in Press	2026-08-10 10:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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