Publication Name	World Journal of Translational Medicine
Manuscript ID	124154
DOI	10.5528/wjtm.124154
Country	Nigeria

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Serum zinc levels, hepatic encephalopathy, and liver disease severity in decompensated chronic liver disease patients in Kano, Nigeria
Manuscript Source	Invited Manuscript
All Author List	Mohammed Gadafi Ahmed Manzo, Nuruddeen Audu, Yusuf Musa, Aliyu Abba Muktar, Adamu Alhaji Samaila and Musa Muhammad Borodo
Funding Agency and Grant Number
Corresponding Author	Yusuf Musa, Chief Physician, Consultant, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Federal Teaching Hospital Katsina, Murtala Muhammad Way, Opposite Jibia Road, Katsina 820101, Nigeria. yusuf.musa@npmcn.edu.ng
Key Words	Zinc; Hepatic encephalopathy; Chronic liver disease; Child-Pugh score; Liver disease severity
Core Tip	Zinc deficiency is frequently seen in patients with decompensated chronic liver disease (DCLD) and appears to worsen as liver disease progresses. In this study, serum zinc levels were significantly lower in DCLD patients and were inversely related to both hepatic encephalopathy (HE) and Child-Pugh class. This suggests that low serum zinc may reflect worsening liver dysfunction. Recent guidelines recommend serum zinc assessment in HE patients not responding to standardized treatment, and a conditional recommendation for zinc supplementation in those found deficient. This reflects the evolving role of zinc both as a biomarker and therapeutic target.
Citation	Manzo MGA, Audu N, Musa Y, Muktar AA, Samaila AA, Borodo MM. Serum zinc levels, hepatic encephalopathy, and liver disease severity in decompensated chronic liver disease patients in Kano, Nigeria. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.124154
PDF	124154-in-press.pdf

Received	2026-06-09 02:38
Peer-Review Started	2026-06-09 02:39
First Decision by Editorial Office Director
Return for Revision	2026-06-24 07:45
Revised	2026-07-07 19:53
Publication Fee Transferred
Second Decision by Editor	2026-07-28 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 10:12
Articles in Press	2026-07-28 10:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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