Publication Name	World Journal of Stem Cells
Manuscript ID	124169
Country	Israel

Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Induced pluripotent stem cell-derived neuronal models in psychiatry: Mechanistic insights and translational horizons
Manuscript Source	Unsolicited Manuscript
All Author List	Moria Maman, Orit Goldman, Talia Cohen Solal and Daphna Laifenfeld
Funding Agency and Grant Number
Corresponding Author	Moria Maman, PhD, Research and Development, NeuroKaire, Yigal Alon 126, Tel Aviv-Yafo 6744332, Tel Aviv, Israel. moria@neurokaire.com
Key Words	Induced pluripotent stem cells; Schizophrenia; Bipolar disorder; Major depressive disorder; Autism spectrum disorder; Attention-deficit hyperactivity disorder; Precision psychiatry; In vitro disease modeling
Core Tip	Human induced pluripotent stem cell-derived neuronal models are transforming psychiatric research by enabling direct investigation of patient-specific neural phenotypes in a human genetic context. Beyond disease modeling, emerging evidence suggests that quantitative functional phenotyping can identify biologically meaningful patient subgroups and treatment-response signatures. This review synthesizes findings across major psychiatric disorders and proposes a conceptual shift from reproducing diagnostic categories in vitro toward mechanism-based stratification. Such approaches may bridge the gap between psychiatric genetics and clinical decision-making, advancing the development of precision psychiatry.
Citation	Maman M, Goldman O, Cohen Solal T, Laifenfeld D. Induced pluripotent stem cell-derived neuronal models in psychiatry: Mechanistic insights and translational horizons. World J Stem Cells 2026; In press

Received	2026-06-09 03:21
Peer-Review Started	2026-06-09 03:21
First Decision by Editorial Office Director
Return for Revision	2026-07-08 06:32
Revised	2026-07-13 07:41
Publication Fee Transferred	2026-07-27 07:07
Second Decision by Editor	2026-08-13 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:45
Articles in Press	2026-08-26 08:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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